Lineage commitment in the mammalian preimplantation embryo
نویسندگان
چکیده
منابع مشابه
Lineage specification in the mouse preimplantation embryo.
During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of ma...
متن کاملEpigenetic regulation in mammalian preimplantation embryo development
Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significant changes. Each preimplantation embryo stage has its own characteristic epige...
متن کاملMulti-lineage 'stem' cells in the mammalian embryo.
The term 'stem' cell has acquired a rather more restricted meaning in cell biology than in embryology as a result of studies on the growth kinetics of renewing tissues in mature organisms. It is normally used in an embryological context as a synonym for 'progenitor' cell. Methods of establishing the existence of multi-lineage progenitor cells in mammals are examined briefly before the occurrenc...
متن کاملCell identity in the preimplantation mammalian embryo: an epigenetic perspective from the mouse
The early preimplantation mouse embryo is a unique system where it is possible to explore the foundations of totipotency and differentiation. Following fertilization, a single cell, the zygote, will give rise to all tissues of the organism. The first signs of differentiation in the embryo are evident at the blastocyst stage with the formation of the trophectoderm, a differentiated tissue that e...
متن کاملCell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis.
Cell adhesion plays a critical role in the differentiation of the trophectoderm epithelium and the morphogenesis of the blastocyst. In the mouse embryo, E-cadherin mediated adhesion initiates at compaction at the 8-cell stage, regulated post-translationally via protein kinase C and other signalling molecules. E-cadherin adhesion organises epithelial polarisation of blastomeres at compaction. Su...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioscientifica Proceedings
سال: 2019
ISSN: 2515-0227
DOI: 10.1530/biosciprocs.8.007